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In COPD patients, single doses of 10 times the maximum recommended therapeutic dose were associated with a moderate increase in pulse rate, systolic blood pressure increase and QTc interval.
Symptoms: An overdose of indacaterol is likely to lead to exaggerated effects typical of β2-adrenergic stimulants ie, tachycardia, tremor, palpitations, headache, nausea, vomiting, drowsiness, ventricular arrhythmias, metabolic acidosis, hypokalaemia and hyperglycaemia.
Treatment: Supportive and symptomatic treatment is indicated. In serious cases, patients should be hospitalised. Use of cardioselective β-blockers may be considered, but only under the supervision of a physician and with extreme caution since the use of β-adrenergic blockers may provoke bronchospasm.
